| 摘要 |
Disclosed is a gastroretentive system for the controlled, continuous release of active pharmaceutical ingredients in the stomach, comprising a) at least one release device for at least one active pharmaceutical ingredient, and b) at least one swelling body that is connected to the release device, wherein the swelling body is based on sodium alginate and, wherein calcium alginate or at least one pharmaceutically acceptable calcium salt selected from the group consisting of calcium acetate, calcium aspartate, calcium carbonate, calcium chloride, calcium citrate, calcium cyclamate, calcium folinate, calcium gluconate, calcium glutamate, calcium lactate, calcium lactate gluconate, calcium phosphate and calcium sulfate and/or at least one pharmaceutically acceptable zinc salt selected from the group consisting of zinc acetate, zinc aspartate, zinc bishydrogen aspartate, zinc chloride and zinc gluconate, and/or at least one pharmaceutically acceptable aluminium salt selected from the group consisting of aluminium hydroxide, algedrate (aluminium oxide) and aluminium phosphate added to the sodium alginate. Also disclosed is a method of producing said system.
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