发明名称 |
2-ARYLMETHYLAZETIDINE-CARBAPENEM-3-CARBOXYLIC ACID ESTER DERIVATIVE OR ITS SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
The present invention provides a 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivatives or their pharmaceutically acceptable salts show high oral absorption rate, and thus can be orally administered. The active metabolites thereof have a broad spectrum of antibacterial activities against Gram-positive and Gram-negative bacteria and excellent antibacterial activities against methicillin-resistant Staphylococcus aurus (MRSA) and quinolone-resistant strains (QRS). In particular, the acid addition salts of the 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivatives are obtained in crystalline forms having excellent stability.
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申请公布号 |
US2011118229(A1) |
申请公布日期 |
2011.05.19 |
申请号 |
US20080742966 |
申请日期 |
2008.11.18 |
申请人 |
KUKJE PHARM. IND. CO., LTD.;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
CHOI YOUNG-RO;KIM BONG-JIN;SONG BOK-JU;LEE BUM-SOO;LEE DONG-WOO;SEO DONG-GEUN;JEONG YOUNG-CHEOL;KIM SI-MIN;KWON JEE-WOONG;KONG JAE-YANG;CHO HEEYEONG |
分类号 |
A61K31/407;A61P31/04;C07D477/06;C07D477/08;C07D477/20 |
主分类号 |
A61K31/407 |
代理机构 |
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