The invention provides compounds which directly inhibit IRE-1a activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
申请公布号
WO2011056744(A1)
申请公布日期
2011.05.12
申请号
WO2010US54940
申请日期
2010.11.01
申请人
MANNKIND CORPORATION;ZENG, QINGPING;WADE, WARREN S.;PATTERSON, JOHN BRUCE
发明人
ZENG, QINGPING;WADE, WARREN S.;PATTERSON, JOHN BRUCE