| 摘要 |
PURPOSE: A compound having an activity of suppressing tyrosinase, isolated from Lespedeza cyrtobotrya MIQ is provided to suppress tyrosinase and to be used as a melanogenesis inhibitor. CONSTITUTION: A cosmetic composition for skin whitening contains 0.05-10.0 weight% of compound of chemical formula 1. The composition suppresses tyrosinase. The composition is used in the form of lotion, cream, essence, cleansing foam, cleansing water, pack, body lotion, body oil, body gel, foundation, or makeup base. A method for isolating the compound from Lespedeza cyrtobotrya MIQ comprises: a step of refluxing Lespedeza cyrtobotrya MIQ with methanol and filtering to obtain methanol extract; a step of suspending the methanol extract into distilled water and shaking with ethyl acetate to obtain an ethyl acetate soluble part; a step of dissolving the ethyl acetate soluble apart in a small amount of methanol; a step of performing gel filtration chromatography to obtain an active fraction; and a step of performing HPLC(High Performance Liquid Chromatography) to obtain a single pre compound.
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