发明名称 |
COMPOSITIONS AND METHODS OF USE OF AN ONCOLYTIC VESICULAR STOMATITIS VIRUS |
摘要 |
<p>Oncolytic VSV viruses have been developed as a strategy for combating cancer. The present invention includes mutant VSV that have one or more mutations in the nucleic acid sequence encoding the viral genome that increase the oncolytic potential of the virus. Pharmaceutical compositions including oncolytic virus disclosed herein are also provided. Pharmaceutical compositions containing virus and one or more excipients may be for systemic or local administration. Methods of administering an effective amount of the compositions for treating cancer are disclosed. Preferred routes of administration include intratumeral and intravenous injection, and intranasal delivery. Administration of the disclosed compositions containing oncolytic viruses may be coupled with surgical, radiologic, other therapeutic approaches to treatment of cancer. Methods of manufacturing mutant VSV viruses exhibiting desired properties include applying selective pressure, and through directed or random mutagenesis.</p> |
申请公布号 |
WO2010080909(A9) |
申请公布日期 |
2011.03.31 |
申请号 |
WO2010US20370 |
申请日期 |
2010.01.07 |
申请人 |
YALE UNIVERSITY;VAN DEN POL, ANTHONY, N.;WOLLMANN, GUIDO |
发明人 |
VAN DEN POL, ANTHONY, N.;WOLLMANN, GUIDO |
分类号 |
C07K14/145;A61K35/76 |
主分类号 |
C07K14/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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