摘要 |
<p>The present invention provides a process for preparation of crystalline aprepitant having not more than 15% by weight of Form I content which comprises, a) dissolving aprepitant in a suitable solvent to obtain a solution, b) cooling the solution to 10-15°C, c) optionally seeding the solution with aprepitant Form I crystals, d) adding an anti-solvent to the solution, and e) isolating crystalline aprepitant having not more than 15% by weight of Form I content.</p> |
申请人 |
RANBAXY LABORATORIES LIMITED;JAIN, DEEPAK, MOHANLAL;KHURANA, MANECK;MEHTA, HITEN, SHARADCHANDRA;TATIYA, ABHAY;NATH, ASOK;GADE, SANJAY, MAHADEO;PRASAD, MOHAN;DHAR, SUBHASH |
发明人 |
JAIN, DEEPAK, MOHANLAL;KHURANA, MANECK;MEHTA, HITEN, SHARADCHANDRA;TATIYA, ABHAY;NATH, ASOK;GADE, SANJAY, MAHADEO;PRASAD, MOHAN;DHAR, SUBHASH |