发明名称 |
SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND USE THEREOF |
摘要 |
The invention relates to antagonists of serotonin 5-HT 6 receptors simultaneously regulating homeostasis of Ca +2 ions in cells, representing substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles of the general formula 1, pharmaceutically acceptable salts and/or hydrate thereof. In the general formula 1:
R 1 represents amino group substituent selected from optionally substituted C 1 -C 5 alkyl; R 2 i is one or more substituents selected from hydrogen, halogen, C 1 -C 3 alkyl, CF 3 , OCF 3 ; Ar is phenyl optionally substituted with halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, substituted amino group, or CF 3 ; or optionally substituted aromatic 6-membered heterocycle comprising 1-2 nitrogen atoms in the cycle; W represents ethylene group -CH 2 -CH 2 -, ethenyl group -CH=CH-, or ethynyl group -C‰¡C-. The invention also relates to the novel compounds selected from the compounds of the general formula 1, methods for their preparation, pharmaceutical compositions and methods of their use. |
申请公布号 |
EP2145887(A4) |
申请公布日期 |
2011.03.02 |
申请号 |
EP20080753899 |
申请日期 |
2008.04.01 |
申请人 |
ALLA CHEM, LLC.;IVASHCHENKO, ANDREY ALEXANDROVICH |
发明人 |
IVASHCHENKO, ANDREY ALEXANDROVICH;IVACHTCHENKO, ALEXANDRE VASILIEVICH;TKACHENKO, SERGEY YEVGENIEVICH;FROLOV, EVGUENI BORISOVICH;MITKIN, OLEG DMITRIEVICH;KRAVCHENKO, DMITRI VLADIMIROVICH;OKUN, ILYA MATUSOVICH;SAVCHUK, NIKOLAY FILIPPOVICH;LAVROVSKY, YAN |
分类号 |
C07D471/04;A61K31/437;A61P37/02;A61P37/08 |
主分类号 |
C07D471/04 |
代理机构 |
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地址 |
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