发明名称 |
METHOD OF PRODUCING 1-ADAMANTANE CARBOXYLIC ACID |
摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to pharmaceutical chemistry, specifically to a method of producing 1-adamantane carboxylic acid which is a basic intermediate product in production of antiviral agent ramantadin. The method of producing 1-adamantane carboxylic acid is realised through carboxylation of 1-nitroxyadamantane with methanoic acid in the presence of sulphuric acid. 1-nitroxyadamantane is dissolved in 93.0-96.0% sulphuric acid containing 0.7-1.0 moles of urea. Methanoic acid or its salt is added in amount of 1.5-2.0 mol per mole of 1-nitroxyadamantane and held at temperature 18-20C for 4-24 hours. The reaction mass is diluted with water at temperature 90-95C and held at temperature 80-90C for 30-40 minutes to complete hydrolysis of the formed 1-nitrourea and 1,3-dinitrourea. Adamantane carboxylic acid is the cooled and filtered. Output of the end product with melting point of 177-180C is theoretically equal to 90-99%. ^ EFFECT: design of an efficient method of obtaining 1-adamantane carboxylic acid. ^ 3 cl, 8 ex |
申请公布号 |
RU2412930(C1) |
申请公布日期 |
2011.02.27 |
申请号 |
RU20090129270 |
申请日期 |
2009.07.29 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE UNITARNOE PREDPRIJATIE "GOSUDARSTVENNYJ NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT "KRISTALL" |
发明人 |
GAN'KIN JURIJ ALEKSANDROVICH;KORNEV MIKHAIL ALEKSANDROVICH;RJABIKOVA NINA SERGEEVNA;KONDJUKOV IVAN ZINOV'EVICH;IL'IN VLADIMIR PETROVICH |
分类号 |
C07C51/097;C07C51/42;C07C51/43;C07C61/135 |
主分类号 |
C07C51/097 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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