Pyrazolylaminopyridine derivatives useful as kinase inhibitors

摘要

Disclosed is a compound of formula (I) wherein one of X1, X2, X3 and X4 is =N-, the other three are independently selected from =CR8, =CR9- and =CR10-, A is a direct bond or optionally substituted C1-2alkylene, Ring C is carbocyclyl or heterocyclyl, and wherein the rest of the substituents are disclosed within the specification. Also disclosed is a process for preparing a compound of formula (I). Also disclosed is the use of a compound of formula (I) in the manufacture of a medicament for use in the inhibition of Trk activity, for the treatment or prophylaxis of cancer or for use in the production of an anti-proliferative effect.