发明名称 |
Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network |
摘要 |
In an aspect, the present invention uses projection micro stereolithography to generate three-dimensional microvessel networks that are capable of supporting and fostering growth of a cell population. For example, provided is a method of making a microvascularized bioreactor via layer-by-layer polymerization of a photocurable liquid composition with repeated patterns of illumination, wherein each layer corresponds to a layer of the desired microvessel network. The plurality of layers are assembled to make a microvascular network. Support structures having different etch rates than the structures that make up the network provides access to manufacturing arbitrary geometries that cannot be made by conventional methods. A cell population is introduced to the external wall of the network to obtain a microvascularized bioreactor. Provided are various methods and related bioreactors, wherein the network wall has a permeability to a biological material that varies within and along the network.
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申请公布号 |
US2011033887(A1) |
申请公布日期 |
2011.02.10 |
申请号 |
US20080679497 |
申请日期 |
2008.09.24 |
申请人 |
FANG NICHOLAS X;XIA CHUNGUANG;COX ANDREW |
发明人 |
FANG NICHOLAS X.;XIA CHUNGUANG;COX ANDREW |
分类号 |
C12M3/00;C12P1/00;G01D18/00;G03F7/20 |
主分类号 |
C12M3/00 |
代理机构 |
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地址 |
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