| 发明名称 |
NOVEL SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE |
| 摘要 |
THE PRESENT INVENTION RELATES TO A NOVEL CLASS OF SULFONAMIDES WHICH ARE ASPARTYL PROTEASES INHIBITORS. IN ONE EMBODIMENT, THIS INVENTION RELATES TO A NOVEL CLASS OF HIV ASPARTLY PROTEASE INHIBITORS CHARACTERIZED BY SPECIFIC STRUCTURAL AND PHYSICOCHEMICAL FEATURES. THIS INVENTION ALSO RELATES TO PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS. THE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS OF THIS INVENTION ARE PARTICULARLY WELL SUITED FOR INHIBITING HIV-1 AND HIV-2 PROTEASE ACTIVITY AND CONSEQUENTLY, MAY BE ADVANTAGEOUSLY USED AS ANTIVIRAL AGENTS AGAINST THE HIV-1 AND HIV-2 VIRUSES. THIS INVENTION ALSO RELATES TO METHODS FOR INHIBITING THE ACTIVITY OF HIV ASPARTLY PROTEASE USING THE COMPOUNDS OF THIS INVENTION AND METHODS FOR SCREENING COMPOUNDS FOR ANTI-HIV ACTIVITY.
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| 申请公布号 |
MY142901(A) |
申请公布日期 |
2011.01.31 |
| 申请号 |
MY1993PI01823 |
申请日期 |
1993.09.08 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
ROGER D. TUNG;MARK A. MURCKO;GOVINDA RAO BHISETTI |
| 分类号 |
C07D215/48;G01N33/53;A61K31/16;A61K31/165;A61K31/17;A61K31/18;A61K31/255;A61K31/27;A61K31/325;A61K31/34;A61K31/341;A61K31/343;A61K31/35;A61K31/40;A61K31/4015;A61K31/403;A61K31/404;A61K31/41;A61K31/415;A61K31/42;A61K31/421;A61K31/4245;A61K31/425;A61K31/426;A61K31/44;A61K31/4402;A61K31/4418;A61K31/4433;A61K31/445;A61K31/47;A61K31/495;A61K31/496;A61K31/505;A61K31/535;A61K31/5375;A61K31/5377;A61K31/63;A61K38/00;A61K38/55;A61P31/12;A61P31/18;C07C307/02;C07C307/06;C07C311/13;C07C311/18;C07C311/29;C07C311/39;C07C311/41;C07C311/46;C07D207/12;C07D207/26;C07D207/27;C07D207/28;C07D209/08;C07D209/10;C07D213/30;C07D231/14;C07D239/22;C07D239/54;C07D263/24;C07D271/08;C07D277/20;C07D277/36;C07D295/12;C07D305/12;C07D307/12;C07D307/14;C07D307/20;C07D307/52;C07D307/64;C07D307/79;C07D403/12;C07D405/12;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D419/14;C07G99/00;C07K5/078;G01N33/569 |
主分类号 |
C07D215/48 |
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