发明名称 |
CITRULINATED FIBRIN-FILAGGRIN CHIMERIC POLYPEPTIDE CAPABLE OF DETECTING THE ANTIBODIES GENERATED IN RHEUMATOID ARTHRITIS |
摘要 |
The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the ± or ² chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease. |
申请公布号 |
EP2161284(A4) |
申请公布日期 |
2011.01.12 |
申请号 |
EP20080761599 |
申请日期 |
2008.04.30 |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA |
发明人 |
HARO VILLAR, ISABEL;GOMARA ELENA, MA JOSE;SANMARTI SALA, RAIMON;PEREZ RODRIGUEZ, MA LUISA |
分类号 |
C07K14/75;A61K38/17;A61K38/36;C07K14/47;G01N33/68 |
主分类号 |
C07K14/75 |
代理机构 |
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代理人 |
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地址 |
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