| 摘要 |
Provided are compositions and methods useful for the non-addictive treatment and prevention of upper respiratory conditions in man and animals, e.g., allergic, non-allergic and mixed rhinitis in man or pharyngitis and IAD in horses. Compositions of the invention comprise effective amounts of a suitable nasal decongestant; a suitable corticosteroid; and a suitable anticholinergic agent. The compositions and methods provided are especially useful for long term use in patients with mixed rhinitis and substantially reduce or eliminate the risk of rhinitis medicamentosa. The compositions and methods of treatment provided also eliminate the risk of adverse sequella seen from therapeutic regimens which employ systemic use of decongestants. The compositions provided can further comprise a suitable aromatic and/or a suitable antihistamine and can also comprise optional suitable antimicrobials, cytokine modulators, leukotriene antagonists, cromolyn sodium, or a suitable NDAID agent.
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