TNF-? GENE THERAPY AGENT CONTAINED IN POLYMERIC MICELLE

摘要

Disclosed is a gene delivery system or the like, which is useful for treatment of intractable cancers including pancreatic cancer and peritoneal dissemination. Specifically disclosed is a pharmaceutical composition contained in a polymeric micelle, said pharmaceutical composition containing an expression plasmid for TNF-a as an active ingredient. The expression plasmid is composed of one of the following block polymers: (1) a block copolymer which has a hydrophilic segment that is composed of a polyethylene glycol or a derivative thereof and a polycationic segment that is composed of a polypeptide; or (2) a block copolymer which has a hydrophilic segment that is composed of a polyethylene glycol or a derivative thereof and a polycationic segment that is composed of a polypeptide, with the hydrophilic segment and the polycationic segment being bonded by a disulfide bond.