发明名称 |
Protection of Virus from Immune Cell Uptake |
摘要 |
The present invention relates to a viral particle. The viral particle has a radius of less than about 1 μm, and at least one peptide comprising at least a biologically active portion of CD47. The present invention also includes a method of increasing the life of a particle in vivo in a mammal. The method includes the steps of expressing at least one peptide comprising at least a biologically active portion of CD47 in a viral particle, and administering the viral particle having CD47 expressed to a mammal, wherein the administered viral particle has a longer half life in the mammal than an otherwise identical viral particle that does not have CD47 expressed thereon.
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申请公布号 |
US2010316570(A1) |
申请公布日期 |
2010.12.16 |
申请号 |
US20100721287 |
申请日期 |
2010.03.10 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
DISCHER DENNIS E.;TSAI RICHARD KUO-AN |
分类号 |
A61K49/00;A61K9/14;A61K35/76;A61P43/00;C12N7/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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