AGENTS THAT SELECTIVELY INHIBIT CD25 ON DENDRITIC CELLS OR T CELLS AND THEIR USE

摘要

Agent that selectively inhibit CD25 on dendritic cells on T cells are disclosed herein. Methods are provided for treating a subject with an immune mediated disease. These methods include administering to the subject a therapeutically effective amount of an agent that selectively inhibits CD25 on dendritic cells, thereby treating the immune mediated disorder in the subject. In other embodiments, methods are provided for treating a subject with a tumor. The methods include administering to the subject a therapeutically effective amount of an agent that selectively inhibits CD25 on T cells, thereby treating the tumor in the subject. Compositions are disclosed that include a composite molecule and a carrier, wherein the composite molecule comprises an agent that selectively binds dendritic cells or an agent that selectively binds T cells, wherein the agent is covalently bound to a CD25 antagonist. Methods for selecting an agent of use in treating an immune mediated disorder are also disclosed.