SELECTIVE INFRACTED-TISSUE-TARGETING BACTERIA AND USE THEREOF

摘要

The present invention relates to bacteria which specifically target infracted tissue and to the use thereof. The present invention provides selective infracted-tissue-targeting bacteria for the first time, and can be used in selectively delivering drugs to the infracted tissue or in selectively imaging the infracted tissue. The infraction-targeting bacteria of the present invention can finish treatments by using antibiotics, and therefore, have remarkable advantages as compared to gene therapy using recombinant viruses. The infraction-targeting bacteria of the present invention have a significantly high affinity and specificity to infracted cardiac muscles or infracted brain tissues, thereby significantly reducing undesired transfections in the organs or tissues other than the heart. The gene expression by the infraction-targeting bacteria of the present invention in infracted cardiac muscles or infracted brain tissues is remotely controllable.