| 摘要 |
<p>7-Fluoro-4-[2-[4-(thieno[3,2-c]pyridin-4-yl)piperazin-1-yl]-2-oxoethyl]-quinoleine-2(1H)-one (I) and its salts are new. 7-Fluoro-4-[2-[4-(thieno[3,2-c]pyridin-4-yl)piperazin-1-yl]-2-oxoethyl]-quinoleine-2(1H)-one of formula (I) and its salts are new. Independent claims are included for (1) the preparation of (I); and (2) preparation of 7-fluoro-2-oxo-4-(2-[4-[thieno[3,2-c]pyridin-4-yl)piperazin-1-yl]ethyl]-1,2-dihydroquinoleine-1-acetamide (II) comprising reaction of 3-(acetyloxy)-5-[(3-fluorophenyl)amino]-5-oxopent-2-enoic acid (III) with 4-(piperazin-1-yl)thieno[3,2-c]pyridine (IV) to obtain (I) reduction of (I) and arylation of the obtained reduced compound using an electrophilic agent i.e. an alkyl halide. [Image].</p> |
