SUSTAINED-RELEASE ANTI-PARASITIC COMPOSITIONS COMPRISING MACROLIDES

摘要

Sustained-release compositions for parenteral administration are provided which comprise on a weight to volume basis: about 5% to 30% of a macrolide compound or mixture of macrolide compounds, about 1% to 10% of a low-HLB surfactant or mixture of low-HLB surfactants; about 1% to 20% of a co-solvent selected from the group consisting of an aromatic alcohol, a cyclic amide and mixtures thereof; and a solvent selected from the group consisting of triglycerides of medium chain fatty acids, glycol esters of medium chain fatty acids and mixtures thereof. A preferred macrolide is moxidectin. These compositions are useful for preventing or treating helminth, acarid or arthropod endo- or ectoparasitic infection or infestation in a warm-blooded animal.