Fremgangsmåder til terapi til faste tumorer der udtrykker CD40-celleoverfladeantigenet
摘要
Methods of therapy are provided for treating a subject for a solid tumor that comprises carcinoma cells expressing the CD40 cell-surface antigen. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a subject in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Binding of the anti-CD40 antibody or suitable antigen-binding fragment thereof beneficially inhibits growth of solid tumors via ADCC-dependent killing of the CD40-expressing carcinoma cells.
申请公布号
DK1680141(T3)
申请公布日期
2010.11.01
申请号
DK20040810418T
申请日期
2004.11.04
申请人
NOVARTIS VACCINES AND DIAGNOSTICS, INC.;XOMA TECHNOLOGY LTD.