GROWTH FACTOR-MODIFIED PROTEIN MATRIX FOR TISSUE ENGINEERING

摘要

PROBLEM TO BE SOLVED: To provide a matrix containing a pharmaceutically active molecule for using in tissue repair, regeneration and/or remodeling and/or drug delivery.

SOLUTION: Proteins are incorporated in a manner to be released by degradation of the matrix, enzymatic action and/or diffusion. One method is to bind heparin to the matrix by either covalent or non-covalent bonding methods to form a heparin-matrix. The heparin then non-covalently binds to heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein containing a crosslinking region (e.g. a factor XIIIa substrate) and a native protein sequence can be constructed. Incorporation of degradable linkages between the matrix and bioactive factors can be particularly useful when long-term drug delivery is desired (e.g. in the case of nerve regeneration).

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