发明名称 |
Transgenic mammals having human IG loci including plural Vh and Vk regions and antibodies produced therefrom |
摘要 |
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and V&kgr;) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
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申请公布号 |
US7820877(B2) |
申请公布日期 |
2010.10.26 |
申请号 |
US20050250805 |
申请日期 |
2005.10.14 |
申请人 |
AMGEN FREMONT INC. |
发明人 |
JAKOBOVITS AYA;KUCHERLAPATI RAJU;KLAPHOLZ SUE;MENDEZ MICHAEL J.;GREEN LARRY |
分类号 |
A01K67/027;A61K39/00;C07K14/415;C07K16/00;C07K16/18;C07K16/24;C07K16/28;C12N5/08;C12N15/09;C12N15/85;C12P21/00;C12P21/08 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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