USE OF CYTOKINE-PRODUCING LACTOCOCCUS STRAIN TO TREAT COLITIS

摘要

PROBLEM TO BE SOLVED: To provide an administration strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, such as IL10 and/or soluble TNF receptor via the oral route.

SOLUTION: There is disclosed an inoculation with a suspension of recombinant cells using gram-positive bacteria such as Bacillus Subtilis, Streptococcus gordonii, Staphylococcus xylosus, or Lactobacillus species which has been engineered to produce the respective proteins such as cytokines or cytokine antagonists.

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