| 发明名称 |
Assays for modulators of parkin activity using S5a as a parkin substrate |
| 摘要 |
The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity.
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| 申请公布号 |
US7790365(B2) |
申请公布日期 |
2010.09.07 |
| 申请号 |
US20080024032 |
申请日期 |
2008.01.31 |
| 申请人 |
ELAN PHARMA INTERNATIONAL LIMITED |
发明人 |
JOHNSTON JENNIFER A.;GOLDBERG ALFRED |
| 分类号 |
C12Q1/00 |
主分类号 |
C12Q1/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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