| 摘要 |
FIELD: medicine. ^ SUBSTANCE: claimed invention relates to chemical and pharmaceutical industry and deals with composition containing ceftriaxone (usually as sodium ceftriaxone) and sulbactam (usually as sodium sulbactam), which additionally includes gelating preparation of aminocarboxylic acid, for instance ethylenediaminetetraacetic acid (EDTA) or its pharmaceutically acceptable salt, for prevention of beta-lactamase-mediated resistance to antibiotics, intended for injection acceptable for its pharmaceutical application. Said compositions proved useful for intramuscular and intravenous introduction as antibiotics for inpatients with serious infections. It has been found that claimed pharmaceutical compositions usually increase resistance to formation of solid particles in solutions for parenteral introduction. Composition can be made in form, which is preserved in hermetically closed container and is to be restored before application. In addition, invention relates to method of said compositions manufacturing. Claimed is method of treating patient with state or disturbance, in which treatment with application of sodium ceftriaxone and/or sodium subactam is indicated. ^ EFFECT: composition possesses high stability during storage and does not form solid particles when diluted. ^ 10 cl |
