NOVEL ANSAMYCIN DERIVATIVES AND THE METHOD FOR MUTATIONAL BIOSYNTHESIS THEREOF

摘要

PURPOSE: A method for preparing novel ansamycin derivative using 3-amino-5-hydroxybenzoic acid(AHBA) biosynthesis gene mutant strain is provided. CONSTITUTION: A non-quinone geldamycin derivative, 17-hydroxy-17-demethoxy-18,21-deketone-geldanamycin(ID-6203) is denoted by chemical formula. The compound is produced by Streptomyces hygriscopicus AC2(deposit number: KCTC 10676BP). The mutated Streptomyces hygriscopicus AC2 is a strain in which AHBA biosynthesis gene is deleted. An anticancer drug contains the non-quinone geldamycin derivative compound as an active ingredient.