CHIMERIC RELAXIN POLYPEPTIDES COMPRISING AN A AND B CHAIN DERIVED FROM DIFFERENT RELAXIN FAMILY PEPTIDES
摘要
<p>Provided herein are modified relaxin polypeptides wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid. Also provided are modified relaxin polypeptides comprising at least an A and a B chain, wherein the A and B chains are derived from different naturally occurring relaxins and wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid.</p>
申请公布号
EP2215114(A1)
申请公布日期
2010.08.11
申请号
EP20080844906
申请日期
2008.10.30
申请人
HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE