发明名称 |
HLA-A2-RESTRICTED T-CELL EPITOPES OF THE RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN AS PEPTIDE-BASED VACCINES |
摘要 |
Respiratory syncytial virus (RSV) fusion protein-specific T-cell epitopes as peptide-based vaccines are disclosed. The isolated peptide contains a human HLA restricted CD8+ T-cell epitope that is specific to RSV F protein. The length of the peptide is no more than 9 or 10 amino acid residues. The peptide may be employed as an immunogen to stimulate cytotoxic T cells, indirectly activate helper T cells type 1, and cause release of cytokines from T cells.
|
申请公布号 |
US2010172925(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20090648563 |
申请日期 |
2009.12.29 |
申请人 |
NATIONAL HEALTH RESEARCH INSTITUTES |
发明人 |
CHOW YEN-HUNG;LIU SHIH-HEN;CHONG PELE CHOI-SING |
分类号 |
A61K39/12;A61K38/08;A61P37/04;C07K7/06 |
主分类号 |
A61K39/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|