发明名称 |
A COMPLEX AND METHOD FOR ENHANCING NUCLEAR DELIVERY |
摘要 |
The use of at least one nucleic acid based nuclear localization signal comprising a natural or synthetic m3G-CAP is shown to increase transmembrane transport of a molecular cargo, in particular large molecules, into the nucleus. The use of natural and synthetic m3G-CAP is disclosed and the effect shown with a natural RNA 5' end nuclear localization signal composed of a 2,2,7-trimethylguanosine CAP (m3G-CAP) coupled to fluorescent Streptavidin in one example, and an antisense oligonucleotide in another. A methylenephosphonate modified m3G-CAP is shown to have improved stability in human serum and in cytosolic extract. |
申请公布号 |
WO2010071587(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
WO2009SE51450 |
申请日期 |
2009.12.17 |
申请人 |
AVARIS AB;SMITH, EDVARD;MORENO, PEDRO;STROEMBERG, ROGER;WENSKA, MALGORZATA |
发明人 |
SMITH, EDVARD;MORENO, PEDRO;STROEMBERG, ROGER;WENSKA, MALGORZATA |
分类号 |
C07H21/02;A61K31/7115;A61K31/712 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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