| 摘要 |
Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases and as controls in assays for the identification of CCR2 antagonists. A compound of the formula (I) or a salt thereof: where: Rand Rare each independently hydrogen, halogen, Calkyl,-CN. or Chaloalkyl, provided that at least one of R1or Ris other than hydrogen; each Ris independently hydrogen; Ris hydrogen; Ris halogen or Calkyl; Ris hydrogen; Xis CR, N or NO; Xand Xare N or NO; Xis CR; Xand Xare each independently selected from CR, N, and NO; each Ris independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted Calkyl, substituted or unsubstituted Calke'yl, substituted or unsubstituted Calkynyl,-CN. =O,-NO,-OR,-OC(O)R-COR-C(O)R,-C(O)NRR,-OC(O)NRR,-NRC(O)R,-NRC(O)NRR,-NRR,-NRCOR,-SR,-S(O)R,-S(O)R,-S(O)NRR,-NRS(O)R, substituted or unsubstituted Caryl, substituted or unsubstituted 5-to 10-membered heteroaryl and substituted or unsubstituted 3-to 10-membered heterocyclyl. |
