发明名称 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY
摘要 <p>Disclosed is a compound which has an inhibitory activity on the production of amyloid-ß and is therefore useful as a therapeutic agent for diseases induced by the production, secretion and/or deposition of amyloid-ß protein. Specifically disclosed is a compound represented by formula (I) [wherein A represents a carbocyclic diyl which may have a substituent, or a heterocyclic diyl which may have a substituent; B represents a carbocyclic group which may have a substituent, or a heterocyclic group which may have a substituent; R1 represents a lower alkyl which may have a substituent, or the like; R2 represents a hydrogen, or the like; and R3a and R3b independently represent a hydrogen, or the like, provided that a compound represented by formula (2) is excluded], a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt.</p>
申请公布号 WO2010047372(A1) 申请公布日期 2010.04.29
申请号 WO2009JP68200 申请日期 2009.10.22
申请人 SHIONOGI & CO., LTD.;YONEZAWA SHUJI;TAMURA YUUSUKE;KOORIYAMA YUUJI;SAKAGUCHI GAKU 发明人 YONEZAWA SHUJI;TAMURA YUUSUKE;KOORIYAMA YUUJI;SAKAGUCHI GAKU
分类号 C07D401/12;A61K31/497;A61K31/506;A61P25/28;A61P43/00;C07D403/12 主分类号 C07D401/12
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