TMPRSS4-SPECIFIC HUMAN ANTIBODY

摘要

PURPOSE: A TMPRSS4(Transmembrane protease, serine 4)-specific human antibody is provided to use in cancer diagnosis, classification, imaging, treatment and prognosis determination. CONSTITUTION: A human antibody which is specific to TMPRSS4 contains heavy chain with heavy chain variable region(VH) or fraction thereof; and light chain containing the light chain variable region(VL) or fragment thereof. The heavy chain of the heavy chain variable region contains heavy chain complementarity determining region(HCDR 1) of amino acid selected from sequence numbers 7-18, HCDR 2 of amino acid selected from sequence numbers 19-31, or HCDR3 of amino acid selected from sequence numbers 32-44. A pharmaceutical composition for preventing and treating cancer in which TMPRSS4 is overexpressed contains TMPRSS4-specific human antibody.