发明名称 |
TETRATHIOL LIGANDS, METAL COMPLEXES, CONJUGATES, AND KITS, THE USE THEREOF IN NUCLEAR MEDICINE DIAGNOSTICS AND ENDORADIONUCLIDE THERAPY, AND METHOD FOR PRODUCING THE TETRATHIOL LIGANDS AND METAL COMPLEXES |
摘要 |
The invention relates to a ligand of formula (I), where (CH-R1) and (CH-R1') are substituted or non-substituted methylene bridges; the individual R1 and R1', and R3 and R3', are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups; and m and n are positive whole numbers, where m represents the number of (CH-R1') groups and n represents the number of (CH-R1) groups; wherein the sum of m and n is in the range from 4 to 10; R2 and R2' are selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted carboxyl groups, substituted or non-substituted aryl groups, or Z; X is a substituted or non-substituted methylene bridge having the formula CHR4 or a non-substituted amino group (N-H) or substituted amino group (N-Z); wherein Z stands for -(CH-R5)p-A, where (CH-R5) represents a substituted or non-substituted methylene bridge, and p is a whole number standing for the number of the (CH-R5) groups, wherein p is in the range from 2 through 8; A represents a linkable unit, wherein R4 and the individual R5 are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups. |
申请公布号 |
WO2010043218(A2) |
申请公布日期 |
2010.04.22 |
申请号 |
WO2009DE50056 |
申请日期 |
2009.10.16 |
申请人 |
FORSCHUNGSZENTRUM DRESDEN - ROSSENDORF E. V.;FOERSTER, CHRISTIAN;PIETZSCH, HANS-JUERGEN;SUHR, MATTHIAS |
发明人 |
FOERSTER, CHRISTIAN;PIETZSCH, HANS-JUERGEN;SUHR, MATTHIAS |
分类号 |
C07D295/185;A61K51/04;A61K51/08;C07D273/01;C07F1/08;C07F5/00;C07F7/22;C07F13/00 |
主分类号 |
C07D295/185 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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