摘要 |
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. |
申请人 |
UNIVERSITY OF WASHINGTON;PHASERX;STAYTON, PATRICK, S.;HOFFMAN, ALAN, S.;CONVERTINE, ANTHONY, J.;BENOIT, DANIELLE;DUVALL, CRAIG, L.;JOHNSON, PAUL;GALL, ANNA |
发明人 |
STAYTON, PATRICK, S.;HOFFMAN, ALAN, S.;CONVERTINE, ANTHONY, J.;BENOIT, DANIELLE;DUVALL, CRAIG, L.;JOHNSON, PAUL;GALL, ANNA |