发明名称 |
USE OF MTOR INHIBITORS TO ENHANCE T CELL IMMUNE RESPONSES |
摘要 |
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog. |
申请公布号 |
WO2010017317(A2) |
申请公布日期 |
2010.02.11 |
申请号 |
WO2009US52886 |
申请日期 |
2009.08.05 |
申请人 |
EMORY UNIVERSITY;AHMED, RAFI;LARSEN, CHRISTIAN, P.;ARAKI, KOICHI |
发明人 |
AHMED, RAFI;LARSEN, CHRISTIAN, P.;ARAKI, KOICHI |
分类号 |
A61K31/4745;A61P31/12;A61P35/00 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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