| 摘要 |
<p>Disclosed is an antagonist of a melanin-concentrating hormone receptor, which is useful as a pharmaceutical agent for central nervous system diseases, cardiovascular diseases and metabolic diseases. Specifically disclosed is a compound represented by formula (I) [wherein Q represents CH or N; R1a, R1b, R1c and R1d independently represent a C1-6 alkyl, a halo-C1-6-alkyl, or the like; R2 represents a hydrogen atom, or the like; R3's independently represent a hydrogen atom, a C1-6 alkyl, or the like, or two R3's together form a bridge such as a methylene; R4a and R4b independently represent a hydrogen atom, a C1-6 alkyl, or the like; Z represents a bicyclic aromatic heterocyclic ring, or the like; Ar represents a benzene ring, or the like; m1 and m2 independently represent a number of 0, 1 or 2; and n represents an integer of 1 to 4] or a pharmaceutically acceptable salt thereof.</p> |
