摘要 |
Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided. |
申请人 |
ACADEMIA SINICA;YU, JOHN;YU, ALICE;KUO, MING-WEI;CHANG, JUI-CHIN |
发明人 |
YU, JOHN;YU, ALICE;KUO, MING-WEI;CHANG, JUI-CHIN |