| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a composition including hydrogel polymer that is volumetrically expansible in response to protonation and deprotonation of pH sensitivity. <P>SOLUTION: The hydrogel polymer is prepared by forming a liquid reaction mixture including (a) a monomer and/or polymer at least part of which are/is sensitive to change in pH, (b) a cross-linking agent, and (c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel can further be treated to maintain non-expanded volume till it expands due to change in pH. These hydrogels can be prepared in various forms including pellets, filaments, and particles. Biomedical applications of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand it in situ. <P>COPYRIGHT: (C)2010,JPO&INPIT |
