| 摘要 |
Disclosed is a suspension system for forming a shape-retentive aggregate of gel particles, comprising: a plurality of gel particles dispersed in a polar liquid or a mixture of two or more polar liquid(s), wherein the polar liquid or at least one of the two or more polar liquids comprise(s) one or more hydroxyl groups and; wherein the gel particles have an average diameter of less than 955 nanometers and a first absolute zeta potential; and, wherein the plurality of gel particles are formed from the suspension polymerization of a monomer or two or monomers, wherein the monomer(s) are selected from the group consisting of a 2-alkenoic acid, a hydroxy(2C - 4C)alkyl 2-alkenoate, a hydroxy(2C - 4C)alkoxy(2C - 4C)alkyl 2-alkenoate, a (1 C - 4C)alkoxy(2C 4C)alkoxy(2C - 4C)alkyl 2-alkenoate and a vicinyl epoxy(1C - 4C)alkyl 2-alkenoate and a combination of two or more thereof in the presence of from 0.01 to 10 mol percent of a surfactant; and wherein the suspension system is suitable to be introduced at a selected introduction rate into a receiving medium wherein the gel particles acquire a second absolute zeta potential which is lower (closer to zero) than the first absolute zeta potential whereupon the gel particles coalesce into a shape-retentive aggregate held together by non-covalent bond physical forces comprising hydrophobic-hydrophilic interactions and hydrogen bonds. The disclosure also relates to the application of the shape-retentive aggregates in orthopedic applications such as tissue scaffolding, cartilage and bone repair, meniscus repair/replacement, artificial spinal discs, artificial tendons and ligaments, and bone defect filler.
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