Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

摘要

Disclosed is the use of a substituted quinoline derivative of formula (Ia) or (Ib), wherein p is 1 to 4, q is 0 to 4, r is 1 to 5, two R6 radicals may be taken together to form a bivalent radical of formula -CH=CH-CH=CH-, R9 is O, or R8 and R9 may together form the radical =N-CH=CH-, and wherein the other substituents are as described in the specification, for treating infections of drug resistant Mycobacterium strains. Also disclosed is a combination of a compound of formula (Ia) or (Ib) as defined above and at least one other antimycobacterial agent.