PYRIDINE DERIVATIVE HAVING TTK INHIBITION ACTIVITY

摘要

The object aims to provide an effective inhibitor of TTK protein kinase and an effective anti-cancer agent.  The object can be achieved by a compound of the invention and inventions related to the compound (e.g., a pharmaceutical composition, a TTK inhibitor).  A novel series of compounds having specific properties which are particularly useful for the preparation of a medicinal product for inhibiting the activity of TTK kinase to treat the diseases can be successfully found.  Particularly, the compound is useful for the treatment of proliferative diseases (e.g., cancer) which occur in the form of a solid tumor or a hematologic tumor and in which it is known that TTK kinase is active.  The compound is particularly useful for diseases including colorectal cancer, breast cancer, lung cancer, prostate cancer, pancreatic cancer, bladder cancer, renal cancer, leukemia, lymphoma and others.