摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new active compound effective for the prevention and/or treatment of dementia-associated diseases, Alzheimer diseases, and glycogen synthase kinase-3-associated symptoms and a method for producing the same. Ž<P>SOLUTION: This free base or its pharmaceutically acceptable salt of an oxy-indole derivative expressed by formula I [wherein, R<SP>1</SP>is H or a 1-3C alkyl; R<SP>2</SP>is hydroxy, a halogeno, trifluoromethyl, cyano, amino, nitro, carboxy, a 1-3C alkyl, a 1-3C alkoxy, a 1-3C alkanoyloxy, a 2-4C alkanoyl, a 1-4C alkanoylamino or the like; and R<SP>3</SP>is hydroxy, a halogeno, nitro, trifluoromethyl, a 1-3C alkyl, cyano, amino or the like] is provided. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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