<p>The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia- related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncated Disc1 genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc1 polypeptide truncated before exon 9; (2) 2 copies of endogenous Disc1 genomic DNA sequence encoding full length Disc1 polypeptide. Also provided are related materials and methods.</p>
申请公布号
WO2010007372(A1)
申请公布日期
2010.01.21
申请号
WO2009GB01757
申请日期
2009.07.16
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;TMRI LIMITED;WYETH PHARMACEUTICALS LNC;SHEN, SANBING;RIEDEL, GERNOT;ST CLAIR, DAVID