Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment.
申请公布号
WO2009134952(A3)
申请公布日期
2010.01.07
申请号
WO2009US42203
申请日期
2009.04.30
申请人
IMMUNOGEN, INC;SINGH, RAJEEVA;KOVTUN, YELENA;WILHELM, SHARON, D.;CHARI, RAVI, V. J.
发明人
SINGH, RAJEEVA;KOVTUN, YELENA;WILHELM, SHARON, D.;CHARI, RAVI, V. J.