发明名称 |
Methods for preparing human skin substitutes from human pluripotent stem cells |
摘要 |
The present invention relates to an ex vivo method for obtaining a population of human keratinocytes derived from human pluripotent stem cells comprising a step of co-culturing human pluripotent stem cells with cells that support ectodermal differentiation in presence of an agent that stimulates epidermal induction and a agent that stimulates terminal differentiation of keratinocytes. A further object of the invention relates to a method for preparing a human skin substitute comprising a step of providing an organotypic culture of the substantially pure homogenous population of human keratinocytes derived from human pluripotent stem cells obtained according to the method of the invention. |
申请公布号 |
AU2009264336(A1) |
申请公布日期 |
2009.12.30 |
申请号 |
AU20090264336 |
申请日期 |
2009.06.23 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) |
发明人 |
CHRISTINE BALDESCHI;MARC PESCHANSKI;GILLES LEMAITRE;HIND GUENOU |
分类号 |
C12N5/07;C12N5/071 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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