| 摘要 |
Title cpds. (I): where X and Y are H or Cl (1 or 2 Cl if 1 it is at 3, if 2 they are at 3, 4, 3, 5 or 2,5) Z is H or F, (if F it is at 3 or 4, either as sole substit. or with 1 or 2 Cl atoms, 1 of which it is at 3 or 4), R is H, 5-methyl-1,3,4-thiadiazolyl-2-thio, 1-methyl-5-tetrazolylthio, 2-tetrazolylthio, 5-phenyl/p-nitro-phenyl/p-methoxyphenyl-1,3,4-oxadiazolyl-2-thio, (methyl)carbamyloxy, MeS, N-pyridino, azido or dithiocarbamoyl, R1 is H, dicyclohexylamine or a pharmaceutically acceptable cation) are prepd. by reacting a 7-aminocephalosporanic acid deriv. with a reactive deriv. of an appropriate acid or by reacting (I, R = OAc) with a heterocyclic thiol, MeSH, pyridine, alkali metal azide or dithiocarbamate. A prefd. cpd. is 7-(3', 4'-dichlorophenylthioacetamido)-3-(1'-methyltetrazol)-5-yl-thiome- thyl)-3-cephem-4-carboxylic acid. |
