发明名称 |
INTERLEUKIN-21 (IL-21) AND IL-21 RECEPTOR (IL-21R) MODULATION OF REGULATORY T CELLS AND FORKHEAD BOX P3 (FOXP3) |
摘要 |
Methods of modulating the level and activity of Tregs and Foxp3 using modulators of IL-21/IL-21 R, i.e., IL-21/IL-21 R agonists (i.e., IL-21 agonists and IL-21R agonists) and IL-21/IL-2 I R antagonists (i.e., IL-21 antagonists and IL-21 R antagonists), are disclosed. IL-21 /IL-21 R agonists and antagonists can be used to enhance immunity or induce immune suppression in vivo, ex vivo and/or in vitro, e.g., for treating, ameliorating or preventing autoimmune or inflammatory disorders, cancers, and infectious disorders. |
申请公布号 |
WO2009100035(A3) |
申请公布日期 |
2009.12.23 |
申请号 |
WO2009US32894 |
申请日期 |
2009.02.02 |
申请人 |
WYETH;CATHOLIC HEALTHCARE WEST D/B/A ST. JOSEPH'S HOSPITAL & MEDICAL CENTER& BARROW NEUROLOGICAL INSTITUTE;SHI, FU-DONG;YOUNG, DEBORAH, A.;COLLINS, MARY;VOLLMER, TIMOTHY;LIU, RUOLAN;PIAO, WENHUA |
发明人 |
SHI, FU-DONG;YOUNG, DEBORAH, A.;COLLINS, MARY;VOLLMER, TIMOTHY;LIU, RUOLAN;PIAO, WENHUA |
分类号 |
A61K38/20;A61K38/17;C07K14/715;C07K16/28 |
主分类号 |
A61K38/20 |
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