PROCESS FOR THE PREPARATION OF NAPHTALENES AND BENZO-FUSED HETEROCYCLIC COMPOUNDS

摘要

The title compds. (I) or its pharmaceutically acceptable salts are produced form hydrolysis of (II). Y is 4- or 5-COOH; X=O or S; R1 is H, halo or C1-4 alkyl; R is (3-pyridyl)-Z; Z is -CH2-, -CO-, or -S-; cyano gp. is attached to 4- or 5-. The rxn. such as e.g. heating of 2-(1-imidazolinemethyl)-3-methylbenzo[b thiophene5-carboxylic ethyl ester and 6N HCl on steam bath, cooling, filtering and drying, crystallize in EtOH/ether.