| 摘要 |
The present invention relates to a matrix-shaped percutaneous preparation comprising fentanyl, which has at least one kind of penetration enhancer for increasing absorptivity of fentanyl and relieving patient's pain for a long time. The penetration enhancer is selected from the group consisting of polyglyceryl-3 oleate (Plurol oleique cc497®), polyethyleneglycol-20 almond glyceride (Crovol PK40®), polyethyleneglycol-12 palm kernel glyceride (Crovol A40®), isopropyl myristate (Crodamol IPM®), isopropyl palmitate (Crodamol IPP®), sorbitan monooleate (Span 80®), oleyl alcohol (Oleyl alcohol®), polyethylene glycol 300 (Polyethylene glycol 300®), and polyoxyglyceride (Labrafil 1944®).
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