N-phenyl-2-pyrimidine-amine derivatives

摘要

Disclosed is a process for the preparation of an amide of formula IV, wherein: R1, R2, R4 and R5 are all hydrogen, R3 is (4-methyl-piperazinyl)-methyl, R6', is 4-(3-pyridyl)-2-pyrimidinamino, R7' is methyl and R8, is hydrogen, or a pharmaceutically acceptable salt or crystal form thereof, by reacting the amide of formula I, wherein: R1 to R5 are as defined above, R6 is -NHC(NH)NH2 , R7 is methyl and R8 is hydrogen; with a compound of formula VI, wherein R10 is 3-pyridyl and R11 is hydrogen or lower alkyl. (62) Divided Out of 552636